Goldsboro, originally Goldsborough, is a city in and the county seat of Wayne County, North Carolina, United States. The population was 3…Goldsboro, originally Goldsborough, is a city in and the county seat of Wayne County, North Carolina, United States. The population was 33,657 at the 2020 census. It is the principal city of and is included in the Goldsboro, North Carolina Metropolitan Statistical Area. The nearby town of Waynesboro was founded in 1787, and Goldsboro was incorporated in 1847. It is the county seat of Wayne County.