Mixon was ruled out for Sunday’s game against the Jacksonville Jaguars due to a sprained ankle suffered against the Chicago Bears in a game-time decision after returning to practice Friday morning, per league sources. There is optimism that he could return to play this week against the Buffalo Bills.

The first quarter of the NFL season is coming to a close, and all the injuries are piling up around the league. The Dallas Cowboys, for example, may be without defensive stalwarts DeMarcus Lawrence and Micah Parsons for some time after both players sustained injuries during Thursday night's win over the New York Giants.