Researchers have discovered how a cell surface protein called Aplp1 can play a role in spreading material responsible for ...

A major research breakthrough on Parkinson's disease revealed that an already FDA-approved cancer drug could help stem the ...

Genetic studies have strongly established a prominent role of α-synuclein (α- syn) missense and multiplication mutations in causing Parkinson's disease (PD). In neurons, α-syn is almost ...

Lewy body diseases (LBDs) are a class of debilitating neurodegenerative disorders linked to the abnormal aggregation of the ...

The major mechanism behind Parkinson’s disease is well established – a toxic form of a protein called alpha-synuclein that accumulates inside neurons in clusters, eventually driving cell death ...

Researchers have discovered a new biomarker for Parkinson’s that could ... did not have misfolded alpha-synuclein, suggesting a different biological basis for their disease.

Parkinson’s disease is a brain disorder that affects movement, making everyday tasks difficult for nearly one million people ...

For example, based on a Parkinson's disease rating scale for motor ... prevent cell-to-cell transfer of pathological alpha-synuclein aggregates and slow disease progression,” says Pagano.

An experimental therapy for Parkinson's disease being developed by ... and also after another alpha-synuclein drug tested in the disease – Biogen's cinpanemab – was abandoned in 2021 after ...

Inhibikase Therapeutics announced disappointing results from a Phase 2 trial for its Parkinson’s disease drug, risvodetinib, ...

New research uncovers how declining protein clearance mechanisms with age lead to Alzheimer’s, Parkinson’s, and other ...