Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a study published in Neuron, researchers report 'seeding' this accumulation through fragments of the ...

Researchers have developed a laboratory model that mimics the pathological aggregation of TDP-43, a key protein in ALS and ...

A consortium of researchers led by the Technical University of Munich (TUM) has systematically investigated the underlying molecular mechanisms of ALS. Among other things, the team discovered that ...

And what makes a new candidate drug called COYA 302, an investigational therapy for ALS, different? COYA 302 is a dual-mechanism investigational biologic combination therapy. To explore this ...

The ALS research landscape is evolving rapidly, with groundbreaking advancements shaping the future of therapeutic ...

This animation focuses on the mechanisms that drive ALS pathogenesis. Nature Research has full responsibility for all editorial content; this content is editorially independent of sponsors.

Spinal cord neurons (purple) in mice with ALS suffer degeneration and glia infiltration (yellow) twice as fast when a synaptic repair mechanism is removed (right-hand image), compared to when it ...