Protein 'seeds' trigger key pathological features of ALS and frontotemporal dementia
Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a study published in Neuron, ...
Hosted on MSN9mon
Newly discovered subtypes and sex differences give insight into molecular mechanisms of ALS
A consortium of researchers led by the Technical University of Munich (TUM) has systematically investigated the underlying molecular mechanisms of ALS. Among other things, the team discovered that ...
Technology Networks3d
New Model Mimics TDP-43 Aggregation in ALS and Frontotemporal Dementia
Researchers have developed a laboratory model that mimics the pathological aggregation of TDP-43, a key protein in ALS and ...
Digital Journal25d
ALS drug failures and why COYA 302 is different
And what makes a new candidate drug called COYA 302, an investigational therapy for ALS, different? COYA 302 is a dual-mechanism investigational biologic combination therapy. To explore this ...
pharmaphorum9d
4th ALS Drug Development Summit
The ALS research landscape is evolving rapidly, with groundbreaking advancements shaping the future of therapeutic ...
EurekAlert!1mon
Synaptic Repair Mechanism Protects Against Neurodegeneration (IMAGE)
Spinal cord neurons (purple) in mice with ALS suffer degeneration and glia infiltration (yellow) twice as fast when a synaptic repair mechanism is removed (right-hand image), compared to when it ...