Hosted on MSN11d
How a crucial DNA repair protein works—and what it means for cancer treatment
DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers ...
Scientists Capture First-Ever Images of Cancer’s Covert DNA Repair Strategy
A new structural blueprint paves the way for improved targeting of cancer cells, particularly those with BRCA1 and BRCA2 ...
Technology Networks11d
Mechanism of Key DNA Repair Protein Advances Cancer Treatment
Scientists at Scripps Research have now captured the first detailed images of the DNA repair protein, Pol-theta, in action, ...
News Medical11d
Breakthrough study sheds light on Pol-theta’s role in DNA repair and cancer
The findings, published in Nature Structural & Molecular Biology on February 28, 2025, illuminate how Pol-theta undergoes a major structural rearrangement when it binds to broken DNA strands.
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Novel mechanism eliminates 'bad' enzyme during gene expression
The process of transcription elongation by RNA polymerase II (Pol II), in which Pol II travels along DNA and synthesizes RNA from DNA, is essential for proper gene expression in all eukaryotic cells.
Nature12y
DNA Replication and Checkpoint Control in S Phase
How would you identify the protein that serves as a connector between DNA helicase and pol-a/primase ... the checkpoint kinase 1 (Chk1) (Figure 4) (Cimprich & Cortez 2008). Little is known ...
Nature4y
DNA Transcription
The process of transcription can be visualized by electron microscopy (Figure 1); in fact ... when the RNA pol binds to the DNA upstream (5′) of the gene at a specialized sequence called ...