DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...
A new structural blueprint paves the way for improved targeting of cancer cells, particularly those with BRCA1 and BRCA2 ...
The findings, published in Nature Structural & Molecular Biology on February 28, 2025, illuminate how Pol-theta undergoes a major structural rearrangement when it binds to broken DNA strands.
The process of transcription can be visualized by electron microscopy (Figure 1); in fact ... when the RNA pol binds to the DNA upstream (5′) of the gene at a specialized sequence called ...
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Novel mechanism eliminates 'bad' enzyme during gene expressionThe process of transcription elongation by RNA polymerase II (Pol II), in which Pol II travels along DNA and synthesizes RNA from DNA, is essential for proper gene expression in all eukaryotic cells.
Scientists at Scripps Research have now captured the first detailed images of the DNA repair protein, Pol-theta, in action, revealing the molecular processes responsible for a range of cancers.
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