that monoubiquitylation of UBD-containing proteins might be achieved without the need for an E3 ligase. Mutations of various UBDs that disrupted the binding to Ub abolished E3-independent ...
News-Medical.Net on MSN7d
Ubiquitination plays a key role in cancer stem cell function and treatment resistanceThis review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, ...
This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), ...
Hosted on MSN5mon
Developing a simple, cost-effective method to identify the targets of a crucial protein-modifying enzymenamed Ub-POD, to quickly and easily label the targets of a given E3 ligase enzyme directly in human cells. The work, which was recently published in the journal Science Advances, was led by Urbi ...
Haisco Pharmaceutical Group Co. Ltd. has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an androgen receptor (AR) ...
Katalytic Therapeutics Inc. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a phosphodiesterase PDE4-targeting ...
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