Over time, edited cells may die if they are outnumbered by unedited ones unencumbered by stress responses ... “It’s true that there are less genotoxic risks with base editors and prime editors, but as ...

e.g. on UV-induced genotoxic stress crucially involved in the development of photoaging and pigment synthesis within skin and ...

Among the novel substrates, RAD50 — a component of the MRE11 complex — was shown to be phosphorylated by ATM in response to genotoxic stress. In addition, the cell-cycle kinase CDK1 was shown ...

Oxidative, genotoxic, and hepatotoxic effects on Nile tilapia showcase the threats to nontarget aquatic species from a new ...