e.g. on UV-induced genotoxic stress crucially involved in the development of photoaging and pigment synthesis within skin and ...

Over time, edited cells may die if they are outnumbered by unedited ones unencumbered by stress responses ... “It’s true that there are less genotoxic risks with base editors and prime editors, but as ...

Among the novel substrates, RAD50 — a component of the MRE11 complex — was shown to be phosphorylated by ATM in response to genotoxic stress. In addition, the cell-cycle kinase CDK1 was shown ...