By assessing the levels of purine metabolites, including inosine, hypoxanthine, xanthine, and uric acid, using a technique called targeted metabolomics, they found that patients with PD have ...

3 The enzymatic determination of xanthine and hypoxanthine was done by a modification of the method of Jørgensen and Poulsen. 4 The modification consisted of the use of 0.16-molar tris buffer ...