RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases ... in diverse taxa in all phylogenetic domains of life. ATP-dependent RNA ligases join 3’-OH ...

Similarly, on fusing an L-histidine-binding RNA sequence to the ribozyme, they noted an increase in ligase activity at increasing concentrations of histidine (a key amino acid). Notably ...

The third assay method, the ligase-mediated extension of an oligonucleotide ... In principle, any DNA sequence thus captured into a circular DNA may be amplified by RCA or HRCA.