Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

Within the NTase domain is an adenylate binding pocket composed of the six peptide motifs (I, Ia, III, IIIa, IV, and V) that define the covalent nucleotidyltransferase enzyme superfamily that includes ...

The study explains how the tRNA ligase complex (tRNA-LC), which is essential for digesting RNA molecules, is negatively regulated by the RTP801 factor. In a mouse model of Alzheimer's disease ...

RNA splicing is a modification of the nascent ... of the oxidoreductase PYROXD1 that maintains the activity of the tRNA ligase complex under aerobic conditions. Non-viral intron knock-ins for ...

Adding these methyl groups enhances RNA stability; however ... Since the degradation of most proteins is mediated by E3 ubiquitin ligases, the team further investigated and identified DTX2 ...

Adding these methyl groups enhances RNA stability; however ... Since the degradation of most proteins is mediated by E3 ubiquitin ligases, the team further investigated and identified DTX2 ...