Also inactive for the Lions are center Frank Ragnow (pectoral), wide receiver Isaiah Williams and left tackle Giovani Manu. For the Seahawks, its offensive tackle Michael Jerrell, guard Sataoa Laumea, linebacker Jerome Baker, defensive linemen Leonard Williams and Byron Murphy and linebackers Uchenna Nwosu and Boye Mafe.

Also inactive is center Frank Ragnow, offensive lineman Giovanni Manu and wide receiver Isaiah Williams. Ragnow was ruled out by Lions head coach Dan Campbell earlier in the week after suffering a partially torn pectoral muscle in the team's Week 3 win over the Arizona Cardinals.

The Seattle Seahawks are seeking their third 4-0 start in franchise history, and their first since the 2020 season. Standing in their way is a quality Detroit Lions team, hungry to end their current six-game losing skid to the Seahawks.

It's also another week with a matchup against a talented wide receiver group. The Lions need to figure out how to stop quarterback Geno Smith, who is 2-0 against Detroit since becoming Seattle's starter in the 2022 season. He has a combined 648 yards with four touchdowns and no interceptions while completing 77% of his passes in those two games.

Here are the latest predictions, picks, and odds for the 2024 NFL Week 4 MNF matchup between the Seattle Seahawks at Detroit Lions.

The Seattle Seahawks defense will be shorthanded against the Detroit Lions on Monday Night Football. The Seahawks have ruled out some of their top defenders, including Leonard Williams, Boye Mafe, Byron Murphy II,

Week 5 proved to be one of the most eventful weeks so far this college football season. Miami avoided a massive upset thanks to a controversial overturned call on the final play of the game. KAT to the Knicks?