Mutations disrupting the interactions of C1 and C2B with diacylglycerol (DAG) and phosphatidylinositol 4,5-bisphosphate (PIP 2) on the plasma membrane induced the gain-of-function state of UNC-13L, ...

C2b and C4b become joined to form ... 89 CFH and C3 are both central to the complement cascades, and successful enhancement of CFH function or inhibition of C3 activation will reduce downstream ...

The impairment of the alternative complement pathway contributes to rare kidney diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). We recently described an aHUS ...

Two anti-CII IgG2a mAbs showed either moderate (C2A-7) or weak (C2A-12) affinity to the collagen. C2B-14 and C2A-12 showed more marked complement activation than C2B-9. I.p. injection of C2B-9 or ...

Mutations disrupting the interactions of C1 and C2B with diacylglycerol (DAG) and phosphatidylinositol 4,5-bisphosphate (PIP 2) on the plasma membrane induced the gain-of-function state of UNC-13L, ...