Results Peak HI-6 and cobalt concentrations occurred within 2 min of administration by both the intravenous and IO routes. Mean areas under the concentration-time curves (SD) to the end of the ...

Background: Current best practice for treating acute severe pain in children is to administer intravenous or intranasal opioid. Intranasal diamorphine offers less traumatic analgesia than the ...

18. Watanabe E, Nishikawa T, Ikawa K, Yamaguchi H, Abematsu T, Nakagawa S, et al. Trough level monitoring of intravenous busulfan to estimate the area under the plasma drug concentration-time curve in ...

Phase II Study of Area Under the Plasma-Concentration-Versus-Time Curve–Based Carboplatin Plus Standard-Dose Intravenous Etoposide in Elderly Patients With Small-Cell Lung Cancer . JCO 17, 3540-3545 ...

Intranasal versus intravenous administration led to a delayed mean fentanyl time to maximum concentration (13 vs 6 min) and lower maximum concentration (1.2 vs 2.0 ng/mL).

The drug concentration-time profiles for nebulized fentanyl and IV fentanyl were shown to be similar when 100–300μg doses of fentanyl were administered to 15 healthy volunteers via inhalation ...

The area under the plasma concentration–time curve (AUC) and the area under the first-torque curve was calculated by the trapezoidal method, the average length of stay. OTC bioavailability was ...