eLife16d
Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids
This important study sheds light on the role of sphingolipids on the maturation of Parkinson's disease-associated Synphilin-1 inclusion bodies (SY1 IBs) on the mitochondrial surface in a yeast model ...
eLife16d
Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids
Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...
C&EN20d
Chronic DSS-Induced Colitis Exacerbates Parkinson’s Disease Phenotype and Its Pathological Features Following Intragastric Rotenone Exposure
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, Gujarat, India Department of Pharmacology and Toxicology, College of ...
Frontiers22d
Brain network and energy imbalance in Parkinson’s disease: linking ATP reduction and α-synuclein pathology
This ATP decline may result in α-synuclein accumulation, autophagy-lysosomal system impairment, neuronal network breakdown and accelerated neurodegeneration. We propose an “ATP Supply–Demand Mismatch ...
Frontiers24d
Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives
This review provides insights into the pathophysiology of Parkinson’s disease, highlighting the mechanisms of neurodegeneration, the role of alpha-synuclein, and the disruption of dopaminergic ...
ScienceAlert25d
Parkinson's Discovery Suggests We Could Already Have an FDA-Approved Treatment
In a paper published last year, an international team of scientists describes how the two proteins work together to help harmful alpha-synuclein protein clumps get into brain cells. "Now that we know ...
The Motley Fool27d
Alpha vs. Beta: When to Use Which Metric?
Alpha measures a manager's skill in adding value to a portfolio beyond market gains. Beta assesses how a stock or fund's volatility compares to the market average. High alpha and low beta indicate ...
C&EN5mon
Novel Heterocyclic Piperazine Amide Derivatives as Alpha-synuclein PET Ligands for Diagnosis of Parkinson’s Disease
These compounds are designed as promising positron emission tomography (PET) ligands targeting alpha-synuclein, offering potential for the diagnosis of neurodegenerative disorders, including Parkinson ...