Get Instant Summarized Text (Gist) A new approach for antimalarial drug development involves using a 'Trojan horse' strategy with prodrugs activated by the human enzyme acylpeptide hydrolase (APEH ...

However, the first cases of artemisinin-resistant field isolates have been reported recently and potential replacement antimalarials are only in the developmental stages. Here, we summarize recent ...

Antimalarial drug resistance is a pressing issue in combating the spread of malaria worldwide. In a new study, researchers from Children's Hospital of Philadelphia (CHOP) discovered a key process ...