Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

Traditional gene knockout methods, including CRISPR-Cas9, typically result in complete ... not entirely eliminate—gene function. Using the model plant Arabidopsis thaliana, the team successfully ...

The team created a Nwd1 knockout (Nwd1 −/−) mice model using the CRISPR-Cas9 genome editing technique. They subsequently investigated the effects of Nwd1 deficiency on liver function and ...

Expanding CRISPR's Potential Since its discovery, CRISPR (“Clustered Regularly Interspaced Short Palindromic Repeats”), which ...

The global humanized liver mice model market is on a strong growth trajectory, fueled by the increasing prevalence of liver ...

Single-cell imaging and mass spectrometry data reveal adenosine in the DNA of mammalian cells can be methylated by METTL3 to form N6-methyladenosine in response to DNA damage.

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

CRISPR-Cas9 burst onto the broader scientific scene in 2012 when a team led by Jennifer Doudna showed that it could be modified to target and cut specific segments of DNA. The CRISPR half of the ...