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本研究创新性采用单引导RNA（sgRNA）结合Cas9或TREX2融合增强型Cas9（EDCas9）基因编辑系统，成功修复USH2A基因c.7595-2144A>G深内含子变异引发的剪接缺陷。通过迷你基因模型和患者源性成纤维细胞实验 ...
研究人员利用 CRISPR/Cas9 技术编辑高粱独脚金内酯（SL）生物合成基因及未知基因。结果显示编辑植株突变稳定、SL 减少、抗 Striga 能力增强，为培育抗 Striga 高粱提供新思路。 高粱（Sorghum bicolor L ...
In this study, we demonstrated the exploitation of CRISPR/Cas9 as a high precision system for editing the composition and function of eECMs. Human mesenchymal stromal/stem cell (hMSC) lines were ...
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