The E3 Saxo Classic - formerly known as the E3 Harelbeke, is a one-day cobbled Classic that had its first edition in 1958. The race was cancelled once in 2020 due to the coronavirus global ...

The E3 ubiquitin ligase Cullin-4A (Cul4A) promotes degradation of normal HOX proteins, but HOXA9 protein fused to NUP98 is resistant to degradation 9, 10.

At first glance, the data obtained with the HD isomers seem to provide compelling evidence that LLPS stimulates the activity of HECT E3s. However, as auto-ubiquitination involves three different ...