Targeted protein degradation has moved well beyond its prologue more than 20 years ago. 1 The number of publications describing different PROTACs (PROteolysis TArgeting Chimeras), molecular glues ...
Proxygen GmbH has divulged molecular glue degraders comprising a cullin-ring E3 ligase (CRL)-binding moiety acting as cyclin-dependent kinase 12 (CDK12)/cyclin K degradation inducers reported to be ...
The E3 Saxo Classic - formerly known as the E3 Harelbeke, is a one-day cobbled Classic that had its first edition in 1958. The race was cancelled once in 2020 due to the coronavirus global ...
© 2025 The Authors. Circulation: Heart Failure is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access ...
Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. In 2015, the United Nations officially launched the Sustainable Development Goals ...
The 'Flatellite' model is designed to help companies and government agencies launch and operate large satellite constellations, which could be used for internet connectivity.
At first glance, the data obtained with the HD isomers seem to provide compelling evidence that LLPS stimulates the activity of HECT E3s. However, as auto-ubiquitination involves three different ...
Diabetic kidney disease (DKD) is a prevalent complication of diabetes mellitus (DM), and its incidence is increasing alongside the number of diabetes cases. Effective treatment and long-term ...
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