Researchers from Tango Therapeutics Inc. have unveiled DNA ligase 1 (LIG1) as a potential new therapeutic target for synthetic lethality in BRCA1-mutant cancers after CRISPR/Cas9 screening.

The viral ligases do not form stable complexes with the following ligands: (i) DNA containing a 1-nucleotide or 2-nucleotide gap; (ii) the sealed duplex DNA product of the ligation reaction; (iii) a ...

However, current methods like DNA ligase-linked hydrogels present many challenges, including potential allergic reactions and complex administration procedures that limit clinical applications.

During the DNA damage response (DDR), repair proteins such as the E3 ubiquitin ligase BRCA1 accumulate at DNA double-stranded breaks (DSBs), and ubiquitylation at these sites helps recruit further ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

However, current methods like DNA ligase-linked hydrogels present many challenges, including potential allergic reactions and ...