A research team led by Prof. Cao Xiaofeng at the Institute of Genetics and Developmental Biology (IGDB) of the Chinese ...

Lysine demethylase 6A (KDM6A) is a demethylase that plays a key role at regulating developmental gene expression signatures in several tissues, including neuronal cells. The KDM6A gene is located in ...

It was subsequently found to drive degradation of subunits in a transcriptional repressor complex ‘LHC’, comprised of the histone demethylase LSD1, the histone deacetylase HDAC1 (or HDAC2 ...

New Delhi: Hetero Healthcare has got approval from the Subject Expert Committee (SEC) functional under the Central Drug ...

A new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes and its implications for human diseases. This article sheds light on how ...

Bomedemstat (IMG-7289) – an oral lysine-specific demethylase 1 (LSD1) inhibitor – is in multiple phase 2 trials for the treatment of indications including essential thrombocythemia (ET ...

Furthermore, we constructed a series of embryonic stem cell lines knocking out the other H3K27 demethylase KDM6A, and depleting both KDM6A and KDM6B, respectively. These cell lines together confirmed ...

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

Researchers have found that specific gut cells, BEST4/CA7+ cells, regulate electrolyte and water balance in response to bacterial toxins that cause diarrhea. Their findings show that these cells ...

The polycythemia vera market over the next few years is expected to substantially change and experience growth, as it will be dominated by two already approved products, Incyte/Novartis' JAKAFI ...