Oxford University Innovations Ltd. has synthesized hypoxia-activated proteolysis targeting chimeras (hypoxia-activated PROTACs; HAP-TAC) comprising a hypoxia-activated moiety modified E3 ubiquitin ...

The RING finger protein 5 (RNF5), an E3 ubiquitin ligase, has demonstrated significant antiviral activity against various viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ...

Despite this, the review could benefit from a more detailed discussion on the UPS’s impact on the transcription factor FOXP3, the regulation of immune cell function by E3 ubiquitin-protein ligases, ...

The authors demonstrate that nsp16 undergoes ubiquitination and subsequent degradation by the host E3 ubiquitin ligases UBR5 and MARCHF7 via the ubiquitin-proteasome system (UPS). Specifically, UBR5 ...

“My heart is filled with excitement, and I can sense the mix of anticipation and eagerness in the air as we celebrate this special Match Day,” said Allison Brashear, MD, MBA, UB’s vice president for ...

E3 ubiquitin (Ub) ligases play crucial roles in diverse cellular processes and their activity is strictly regulated. HECT-type E3 Itch is activated and recruited to lipid droplets by Spartin to ...

(E) Venn diagram showing overlap of E3 ligases related to ERα and proteins interacting with ... (H-I) HEK293T (H) and T47D (I) cells were co-transfected with Flag-ERα, HA-Ub and FRMD8 siRNA as ...

The Board of Trustees of the University of The Bahamas (UB) has announced the selection of Dr. Robert Blaine III as UB’s next president. Blaine was one of 90 local and international candidates. His ...