This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, ...

named Ub-POD, to quickly and easily label the targets of a given E3 ligase enzyme directly in human cells. The work, which was recently published in the journal Science Advances, was led by Urbi ...

Kymera Therapeutics Inc. has described proteolysis targeting chimera (PROTACs) compounds comprising an E3 ubiquitin ligase-binding moiety covalently linked to a signal transducer and activator of ...

The authors showed that deleting the C2 domain led to the increased formation of Ub linkages to the catalytic ... was found to be conserved in several E3 ligases that have a C2–WW–HECT domain ...