Albumin binding to FcRn, GP60, and SPARC results in an improved PK profile, decreased toxicity risk, and a broader therapeutic index preclinically, with significant targeting of the tumor ...

However, additional mechanisms are possible. For example, binding of albumin to Gp60 triggers transcytosis by phosphorylating Src family tyrosine kinases and caveolin-1. 111 That will increase ...

(B) Describes the proposed mechanism of uptake of HMCD-drug conjugates into tumor cells. Albumin-bound HMCDs bind to caveloin-1 associated Gp60 receptors, triggering caveolae-mediated transcytosis ...

A new study published in Mycology highlights the alarming evolutionary rate of Sporothrix, the fungus that causes ...

Sonnet BioTherapeutics Holdings, Inc. announced that the United States Patent and Trademark Office has issued a Notice of Allowance for a new patent related to its modified form of Interleukin-18 ...

Martha graduated from University of Cambridge with a BA in Natural Sciences and went on to do a PhD in cell biology at University College London. She then undertook postdoctoral work at Massachusetts ...