Scientific Research Publishing22d
SIRT1 Regulates Autophagy and Activation of Microglia through Smad3/TRIB3 Signaling Axis to Improve Spinal Cord Injury ()
Department of Rehabilitation Medicine, Qujing No. 1 Hospital, Qujing, China. To sum up, the objective of this research was to thoroughly explore SIRT1’s role and interplay in controlling microglial ...
Frontiers11d
Ultrastructural evidence for the activation of autophagy and analysis of the protective role of autophagy in goat spermatozoa under liquid storage
Autophagy as a cellular catabolic process plays critical roles ... the samples were incubated with antibodies anti-LC3B (Abcam, ab192890, 1:200), anti-ATG5 (Abcam, ab108327, 1:100), anti-p62 (Abcam, ...
Frontiers18d
Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1β Expression in Primary Mouse Cardiac Fibroblasts
However, the autophagy inhibitor chloroquine effectively degraded pro ... Immune Fluorescence Microscopy and LC3B Puncta Quantification To evaluate the LC3B dots in cardiac fibroblasts, 15,000 cells ...
The EMBO Journal22d
Caspase cleavage of influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production
Previous studies have reported that disruption of the M2 LIR motif reduces LC3B lipidation during infection (Beale et al, 2014). To analyze the role of M2 cleavage, we assessed LC3B lipidation induced ...
eLife5d
Novel mechanism for tubular injury in nephropathic cystinosis
Strengths: The implications for health, disease, and therapeutic discovery are considerable, given the central role of autophagy and lysosome-related pathways in regulating critical cellular processes ...
ahajournals.org7d
Nrf3-Mediated Mitochondrial Superoxide Promotes Cardiomyocyte Apoptosis and Impairs Cardiac Functions by Suppressing Pitx2
Myocardial infarction (MI) elicits mitochondria reactive oxygen species (ROS) production and cardiomyocyte (CM) apoptosis. Nrf3 (nuclear factor erythroid 2-related factor 3) has an established role in ...
University of Surrey11d
Professor Rachel Simmonds FRSB
Research in my group focusses on the mechanism of action of mycolactone, the lipid-like exotoxin of the Buruli ulcer infectious agent, Mycobacterium ulcerans. Mycolactone has many unusual and ...