eLife27d
Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis
In TFEB KO cells, this increase of surface LAMP1 signal by SFN treatment was significantly ... subsequent activation of autophagy-related genes, exocytosis of lysosomes, and reduction in lysosomal ...
eLife9d
Endosomal-lysosomal organellar assembly (ELYSA) structures coordinate lysosomal degradation systems through mammalian oocyte-to-embryo transition
After fertilization, the embryo degrades parts of the maternal components via lysosomal degradation systems, including autophagy and endocytosis, as zygotic gene expression begins during embryogenesis ...
Frontiers24d
Molecular mechanism on autophagy associated cardiovascular dysfunction in Drosophila melanogaster
As a crucial cellular process involved in degrading and recycling damaged organelles and proteins, autophagy-related (ATG) proteins mediated autophagy plays a significant role in various physiological ...
Frontiers21d
Neuronopathic Gaucher disease: Beyond lysosomal dysfunction
They could also result from indirect interactions between lysosomes and other organelles by activating signaling pathways or alterations in these organelles such as exosomes, autophagosomes in ...