Targeted Oncology provides news, videos, and reviews on the rapidly evolving world of targeted therapies and immunotherapy ...

According to the company description, while existing TPD technology utilizes specific E3 ubiquitin ligases to degrade proteins, Prazer Therapeutics' proprietary platform (SPiDEM™) can utilize various ...

Multi-epitope immunopurifications of huntingtin (HTT) from vulnerable brain regions of Huntington’s disease (HD) models ...

The following is a summary of “Ocular features of VEXAS syndrome: a systematic review and meta-analysis,” published in the ...

Kymera Therapeutics Inc. has described proteolysis targeting chimera (PROTACs) compounds comprising an E3 ubiquitin ligase-binding moiety covalently linked to a signal transducer and activator of ...

When is The Witcher 4 release date? CD Projekt Red initially confirmed the existence of a new game in The Witcher series via a press release in March 2022 and a title update in October 2022.

NRX-0305 is a potent, selective, and orally bioavailable mutant-specific BRAF degrader that Nurix is exploring for use in oncology. Nurix has reported preclinical data demonstrating potent anti-tumor ...

Transgenic animals continue to play an essential role in many aspects of zebrafish research, including the development of disease models. The most widely used system for zebrafish transgenesis is the ...

MARCHF7 and UBR5 were identified as E3 ubiquitin ligases involves in nsp16 protein degradation ... The other experimental methods were the same as C. Figure 4. MARCHF7 and UBR5 directly interact with ...

Sonic 4 is in the works, with a release date already set for the sequel. It's a few years away, but that's OK, because even speedy hedgehogs and their pals need to pace themselves. Following the ...

We thank Dr. Pilong Li for polySH3 5 and polyPRM 5 plasmids, Dr. Yanhui Xu for FKBP12 and mTOR genes, and Dr. Hongrui Wang for Nedd4 and Smurf1 genes. LC3B KO HeLa cell line was a kind gift from Dr.