Katalytic Therapeutics Inc. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a phosphodiesterase PDE4-targeting ...

Shenzhen Zhongge Biotechnology Co. Ltd. has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an interleukin-1 ...

In the case of a PROTAC, this binding involves an E3 ligase. Figure 1: An illustration from Arvinas showing the mechanism of proteolysis-targeting chimeras (PROTACs). Ultimately, the disease ...

Multiple E3 ubiquitin ligases and deubiquitinating enzymes ... However, new strategies, including PROTAC, aim to enhance specificity and reduce toxicity in solid tumors. This study underscores ...

PROTAC compounds are designed to bind to a target protein and recruit an E3 ubiquitin ligase, tagging the target for degradation by the proteasome. These compounds enable the selective removal of ...

A degrader molecule, either PROTAC or molecular glue, brings the protein of interest (POI) and E3 ubiquitin ligase in close proximity and engages the ubiquitin-proteasome system (UPS), the cellular ...

The E3 Saxo Classic - formerly known as the E3 Harelbeke, is a one-day cobbled Classic that had its first edition in 1958. The race was cancelled once in 2020 due to the coronavirus global ...

This study by Wu et al. provides valuable computational insights into PROTAC-related protein complexes, focusing on linker roles, protein-protein interaction stability, and lysine residue ...