Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...

Within the NTase domain is an adenylate binding pocket composed of the six peptide motifs (I, Ia, III, IIIa, IV, and V) that define the covalent nucleotidyltransferase enzyme superfamily that includes ...

RNA splicing is a modification of the nascent ... of the oxidoreductase PYROXD1 that maintains the activity of the tRNA ligase complex under aerobic conditions. Non-viral intron knock-ins for ...

The research team discovered a novel method that uses ligase ribozymes to trigger linear RNA into autonomously folding itself, enabling the efficient production of high-purity circRNA, he said. The ...

reveal the mechanistic basis for the protective function of the oxidoreductase PYROXD1 that maintains the activity of the tRNA ligase complex under aerobic conditions. DNA:RNA hybrids are linked ...