Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

Within the NTase domain is an adenylate binding pocket composed of the six peptide motifs (I, Ia, III, IIIa, IV, and V) that define the covalent nucleotidyltransferase enzyme superfamily that includes ...

The study explains how the tRNA ligase complex (tRNA-LC), which is essential for digesting RNA molecules, is negatively regulated by the RTP801 factor. In a mouse model of Alzheimer's disease ...

Upregulation of a synergistic defense mechanism involving AGO18-mediated RNA interference and reactive oxygen species (ROS), ...

Many techniques add oligonucleotides to microRNA transcripts using RNA ligase, but that enzyme favors certain sequences over others. Enzymes that add other labels also have preferences.

The research team discovered a novel method that uses ligase ribozymes to trigger linear RNA into autonomously folding itself, enabling the efficient production of high-purity circRNA, he said. The ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...