The major safety concerns in the top-down approach include TB, opportunistic infections, neutralizing antidrug antibody formation, autoimmunity, malignancy, lymphoma, cardiovascular or ...

Read the marketing material for any fund and you'll often find the manager saying that they take either a "top-down" or a "bottom-up" approach. Sometimes they claim to do both: "the fund combines ...

At the World Congress of Gastroenterology in September, I had the opportunity to debate the benefits of a 'top-down' approach to the treatment of Crohn's disease, beginning with biologic (anti ...

The top-down approach relies heavily on photolithography, a process where light is used to transfer geometric patterns from a mask to a light-sensitive chemical photoresist on the substrate.

an emerging approach known as 'top-down' is beginning to make headlines, especially for the analysis of post-translational modifications (PTMs). PTMs often occur in different combinations on ...