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CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...
本研究创新性采用单引导RNA（sgRNA）结合Cas9或TREX2融合增强型Cas9（EDCas9）基因编辑系统，成功修复USH2A基因c.7595-2144A>G深内含子变异引发的剪接缺陷。通过迷你基因模型和患者源性成纤维细胞实验 ...
研究人员利用 CRISPR/Cas9 技术编辑高粱独脚金内酯（SL）生物合成基因及未知基因。结果显示编辑植株突变稳定、SL 减少、抗 Striga 能力增强，为培育抗 Striga 高粱提供新思路。 高粱（Sorghum bicolor L ...
In this study, we demonstrated the exploitation of CRISPR/Cas9 as a high precision system for editing the composition and function of eECMs. Human mesenchymal stromal/stem cell (hMSC) lines were ...
Department of Molecular and Environmental Biotechnology, Faculty of Biology and Biotechnology, University of Science, Ho Chi Minh City 700000, Vietnam Vietnam National University, Ho Chi Minh City ...
The development of precise and efficient delivery systems is pivotal for advancing CRISPR/Cas9 gene-editing technologies, particularly for therapeutic applications. Engineered metal–organic frameworks ...
Cas9, the first Cas protein repurposed for cutting DNA, introduces double-strand breaks that recruit DNA repair machinery. Despite its successes, the CRISPR-Cas9 system has several limitations, ...
Deanna earned their PhD in cellular biology from McGill University in 2020 and has a professional background in medical writing. They are an associate science editor at The Scientist. View Full ...
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