Proxygen GmbH has divulged molecular glue degraders comprising a cullin-ring E3 ligase (CRL)-binding moiety acting as cyclin-dependent kinase 12 (CDK12)/cyclin K degradation inducers reported to be ...
© 2025 The Authors. Circulation: Heart Failure is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access ...
Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China ...
Request permissions for this article. Eppley Institute for Research in Cancer and Allied DiseasesUniversity of Nebraska Medical Center Omaha NE USA Fred & Pamela Buffett Cancer CenterUniversity of ...
Once the target protein and E3 ligase are united in a ternary complex ... labelled DCAF16 [DNA damage-binding protein 1 (DDB1) and Cullin 4 (CUL4)-Associated Factor 16] and increasing ...
Launch provider Rocket Lab is introducing a new satellite model that could help it and other companies operate space-based internet systems to rival Starlink. Rocket Lab's Flatellite satellite is ...
Technology developed in symbiosis with the natural world to meet the challenges of our time and create a more sustainable future E3 – Balanced Solutions for a Better World As a university we have a ...
This month's cover highlights the article Boosting human immunology: Harnessing the potential of immune organoids by Dirk Baumjohann and Maximilian Moll. The review article explores recent advances in ...
Defective in cullin neddylation 1 (DCN1) serves as a co-E3 ligase, which can simultaneously bind E2 UBE2M and cullin proteins to stabilize the catalytic center of the Cullin-Ring E3 ligase complex, ...
We and others have recently provided genetic evidence showing that E3-ubiquitin ligases are associated with bone metabolism, the immune system and inflammation through ubiquitylation and subsequent ...
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