Sanofi has returned to Nurix Therapeutics for another autoimmune candidate, paying $15 million and committing up to $465 ...
Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, ...
1). Thus, we propose that i) the negative effect of 1,6-HD on HECT E3 auto-polyubiquitination is not due to its potential to interfere with LLPS, and ii) additional experiments/evidence are required ...
We thank Dr. Pilong Li for polySH3 5 and polyPRM 5 plasmids, Dr. Yanhui Xu for FKBP12 and mTOR genes, and Dr. Hongrui Wang for Nedd4 and Smurf1 genes. LC3B KO HeLa cell line was a kind gift from Dr.
The RNF217gene is a target of Tet1 and uses its E3 ubiquitin ligase activity to regulate the ubiquitination and subsequent degradation of FPN (19). In addition, iron ions not only mediate the ...
Medicinal Chemistry, Monash Institute of Pharmaceutical Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia Drug Delivery, Disposition & Dynamics, Monash Institute of ...
© 2025 The Authors. Circulation: Heart Failure is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access ...
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