The findings, published in Nature Structural & Molecular Biology on February 28, 2025, illuminate how Pol-theta undergoes a major structural rearrangement when it binds to broken DNA strands.
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New study challenges longstanding assumption about the cause of the genome's most common mutationTo test their hypothesis, the researchers developed a new and very sensitive DNA sequencing technology that could discern genuine errors made by Pol ε during DNA replication from experimental ...
The findings, published in Nature Structural & Molecular Biology, illuminate how Pol-theta undergoes a major structural rearrangement when it binds to broken DNA strands. By unveiling Pol-theta's ...
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Novel mechanism eliminates 'bad' enzyme during gene expressionThe process of transcription elongation by RNA polymerase II (Pol II), in which Pol II travels along DNA and synthesizes RNA from DNA, is essential for proper gene expression in all eukaryotic cells.
DNA polymerase beta (Pol β) is the primary enzyme responsible for processing 1-nt gaps in chromatin during DNA repair. Here, the authors determine the kinetic and structural basis of gap-filling ...
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