The Hippo pathway regulates tissue growth and organ size, and inactivation contributes to cancer. Signals flow through Mst/Lats kinases, which phosphorylate and promote cytoplasmic localization of the ...

Discover 9 promising small molecule drug discovery companies that recently raised funding for their potentially breakthrough ...

Yang and her team at HSDM have spent years studying cell signaling. One of the pathways they focus on is the Hippo/YAP pathway—a signaling pathway crucial for regulating cell growth related to ...

5-hydroxymethylcytosine as a liquid biopsy biomarker in colorectal cancer. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers Symposium. This abstract does not include a full ...

The pig cardiomyocyte cells also showed upregulation of three signaling pathways -- the Mitogen-Activated Protein Kinase pathway, the HIPPO/YAP pathway and the Transforming Growth Factor Β pathway.

MANILA, Philippines -- James Yap has opened a new chapter in his basketball career with a new jersey number. Yap, whose No. 18 is one of the most iconic in PBA history, will switch to No. 15 now ...

"This is the first clinical proof-of-concept for drugging the Hippo-YAP-TEAD pathway," said presenter and lead author Timothy A. Yap, M.D., Ph.D., associate professor of Investigational Cancer ...

The Hippo-YAP (yes-associated protein) signaling pathway is modulated in response to various environmental cues. Activation of YAP in vascular smooth muscle cells conveys the extracellular matrix ...

found that removing Hippo signaling did not impair the ability of the studied organs to grow to their normal size. What’s more, the authors found that the transcriptional activity of Yap/Taz/Yki ...

The transcription factor TEAD, together with its coactivator YAP/TAZ, is a key transcriptional modulator of the Hippo pathway. Activation of TEAD transcription by YAP has been implicated in a number ...

The Hippo signaling pathway controls cell proliferation and tissue regeneration via its transcriptional effectors yes-associated protein (YAP) and transcriptional ...