SciELO14d
Dynactin knockdown leads to synuclein aggregation by blocking autophagy in a zebrafish model of Parkinson's disease
Then, dynactin-siRNA knockdown was performed in the SH-SY5Y cell line and the autophagy flow pathway and status of the retrograde axonal transport were investigated. Zebrafish larvae at 72 hpf were ...
Frontiers14d
New use of an old drug: mechanism of oseltamivir phosphate inhibiting liver cancer through regulation of lipophagy via NEU1
Following dewaxing, rehydration, and antigen retrieval steps, the slides were incubated with specific primary antibodies against NEU1, PLIN2 and LC3B-II. Then, the sections were incubated with the ...
eLife19d
Novel mechanism for tubular injury in nephropathic cystinosis
Division of Multi-Organ Transplantation, Department of Surgery, University of California, San Francisco, United States; Bakar Computational Health Sciences Institute, University of California, San ...
Frontiers20d
Parishin A ameliorates cognitive decline by promoting PS1 autophagy in Alzheimer’s disease
The mCherry-GFP-LC3B plasmid was utilized to establish a dual fluorescence autophagy system for assessing autophagy flux. In brief, cultured cells in a 6-well plate were transfected with the ...
ahajournals.org21d
Nrf3-Mediated Mitochondrial Superoxide Promotes Cardiomyocyte Apoptosis and Impairs Cardiac Functions by Suppressing Pitx2
Myocardial infarction (MI) elicits mitochondria reactive oxygen species (ROS) production and cardiomyocyte (CM) apoptosis. Nrf3 (nuclear factor erythroid 2-related factor 3) has an established role in ...
University of Surrey25d
Professor Rachel Simmonds FRSB
Research in my group focusses on the mechanism of action of mycolactone, the lipid-like exotoxin of the Buruli ulcer infectious agent, Mycobacterium ulcerans. Mycolactone has many unusual and ...
eLife26d
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, United States; Department of Microbiology, UMass Chan Medical School, United States; ...
C&EN28d
Crystal Structure of Autophagy-Associated Protein 8 at 1.36 Å Resolution and Its Inhibitory Interactions with Indole Analogs
State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China ...