eLife27d
Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis
In TFEB KO cells, this increase of surface LAMP1 signal by SFN treatment was significantly ... subsequent activation of autophagy-related genes, exocytosis of lysosomes, and reduction in lysosomal ...
The EMBO Journal1mon
X-linked myopathy with excessive autophagy: characterization and therapy testing in a zebrafish model
X-linked myopathy with excessive autophagy (XMEA) is a rare disease for which pre-clinical models lack, challenging the ability to understand mechanisms and therapies. The use of the zebrafish to ...
Frontiers2mon
αAsarone alleviates neuronal injury by facilitating autophagy via miR-499-5p/PDCD4/ATG5 signaling pathway in ischemia stroke
Methods: The effects of αAsarone on autophagy were examined by WB ... Antibodies for ATG5, LC3I, and LC3II were obtained from Proteintech. The PDCD4, LAMP1, goat anti-mouse and goat anti-rabbit were ...
Frontiers3y
Organization of Presynaptic Autophagy-Related Processes
Further proteins detected in SV preparations include the lysosomal-associated membrane protein LAMP1, the E3-ubiquitin ligase Parkin ... list of players in endocytosis-associated initiation of ...
eLife5y
Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons
These puncta may represent either the self-association of OPTN or the recruitment of OPTN to other autophagy substrates ... of damaged mitochondria by monitoring the recruitment of LAMP1, a late ...