We thank Dr. Pilong Li for polySH3 5 and polyPRM 5 plasmids, Dr. Yanhui Xu for FKBP12 and mTOR genes, and Dr. Hongrui Wang for Nedd4 and Smurf1 genes. LC3B KO HeLa cell line was a kind gift from Dr.

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Background Development of diffuse-type gastric cancer (DGC) starts with intramucosal lesions that are primarily composed of ...

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

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Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Bacteria in polymicrobial habitats are ...

E3 ubiquitin (Ub) ligases play crucial roles in diverse cellular processes and their activity is strictly regulated. HECT-type E3 Itch is activated and recruited to lipid droplets by Spartin to ...