The dopamine precursor levodopa is central to treatment for Parkinson's disease, but causes dyskinetic involuntary movements in many patients. Investigations carried out in Canada show that ...

Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of ...

The finding that mitochondrial toxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and rotenone reproduce the phenotypes in animal models of PD strengthens the involvement of ...

Exp Neurol. 2008; published online July 31.

A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for ...

The Women’s Eastern Reception, Diagnostic and Correctional Center is the first Missouri prison to welcome incarcerated people ...

VANDALIA — A five-year prison trial aims to study how improved prison conditions affect conduct violations and recidivism seen in incarcerated people. The Missouri Prison Transformation ...

Purpose: The pharmacology, pharmacokinetics, clinical efficacy, and safety of rasagiline are reviewed. Summary: Rasagiline is a novel, investigational propargylamine that irreversibly and ...

Two housing units at the Women's Eastern Reception, Diagnostic and Correctional Center have been renovated as part of the Missouri Prison Transformation Project.