Lipinski's 'rule of five' has been the leading measure of 'drug-likeness' for many companies since its publication 10 years ago. However, recent trends reveal that the physical properties of ...

Because the drugs are dispersed in a suspension before ... The lead authors of the paper, which appears today in Nature Chemical Engineering, are former MIT and BWH postdoc Vivian Feig, who ...

potentially rendering these important drugs less effective. A new study, published today in Nature Chemistry by researchers from the University of Pittsburgh and Yale University, shows how common ...

That process led to the group discovering a lasso peptide that exhibited broad-spectrum antibiotic activity and was effective at killing both gram-positive and gram-negative pathogenic bacteria, along ...

T he discovery of a new preclinical compound with strong antifungal activity against multidrug-resistant pathogens is ...