TgF344-AD rats express human APP with the Swedish mutation and human PSEN1 with the Δ exon 9 mutation. Both transgenes are driven by the mouse prion promoter (Cohen et al., 2013). Compared with levels ...

The genetic basis of familial AD (FAD) is closely related to mutations in the APP and PSEN1 genes, which affect APP processing and Aβ production, highlighting the key role of Aβ in the pathogenesis of ...

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Neurodegenerative diseases of the central nervous system (CNS) are characterized by progressive neuronal death and neurological dysfunction, leading to increased disability and a loss of cognitive or ...