While the clinical dementia findings did not reach statistical significance, they were the first to provide a hint that early ...

Before this diagnosis, the youngest Alzheimer's patient was 21 years old, who carried the PSEN1 gene mutation, which causes abnormal proteins to build up in the brain, forming clumps of toxic plaques, ...

Before this diagnosis in China, the youngest patient with Alzheimer's was 21 years old. They carried the PSEN1 gene mutation, which causes abnormal proteins to build up in the brain, forming clumps of ...

Jaime Bortz at home in Buffalo, New York. At 39, a few years since being diagnosed with Alzheimer's, her memory loss is accelerating.Kate Warren for BI ...

This observation echoes what had previously been seen in another DIAD "escapee" who also had a mutation in the PSEN1 gene, Jean-Charles Lambert, an Alzheimer's researcher from the Inserm Institute ...

We recently reported evidence that FAD mutations in APP and PSEN1 cause deficiencies in early steps in processive proteolysis of APP substrate C99 and that this results from stalled γ-secretase enzyme ...

Arafi et al. present results of studies designed to better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP). This ...

These pages give an overview of what genes are and how they are involved in the different diseases that cause dementia. You will also find information about genetic testing for dementia. Genes ...