Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

Within the NTase domain is an adenylate binding pocket composed of the six peptide motifs (I, Ia, III, IIIa, IV, and V) that define the covalent nucleotidyltransferase enzyme superfamily that includes ...

A new study has uncovered a molecular mechanism by which rice cells perceive viral infections and initiate antiviral response ...

Many techniques add oligonucleotides to microRNA transcripts using RNA ligase, but that enzyme favors certain sequences over others. Enzymes that add other labels also have preferences.

The research team discovered a novel method that uses ligase ribozymes to trigger linear RNA into autonomously folding itself, enabling the efficient production of high-purity circRNA, he said. The ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...

RNA splicing is a modification of the nascent ... of the oxidoreductase PYROXD1 that maintains the activity of the tRNA ligase complex under aerobic conditions. Non-viral intron knock-ins for ...

Adding these methyl groups enhances RNA stability; however ... Since the degradation of most proteins is mediated by E3 ubiquitin ligases, the team further investigated and identified DTX2 ...