RNA splicing is a modification of the nascent ... of the oxidoreductase PYROXD1 that maintains the activity of the tRNA ligase complex under aerobic conditions. Non-viral intron knock-ins for ...

A new study has uncovered a molecular mechanism by which rice cells perceive viral infections and initiate antiviral response ...

First, we showcased the remarkable capabilities of our engineered RNA ligase enzymes that can increase the efficiency of conventional chemical siRNA synthesis. Second, we demonstrated the broad ...

Officinae Bio's AI-driven sequence optimization expands Maravai's family of brands, enabling rapid, cost-effective nucleic acid therapy development Venice, Italy-based Officinae Bio's proprietary ...

Get Instant Summarized Text (Gist) A computational tool named NuFold has been developed to model 3D RNA structures, potentially accelerating medical discoveries by decades. This tool addresses the ...

Abstract: The Parkin RBR E3 Ubiquitin Protein Ligase gene, the second largest gene within the ... gene is approximately 1,300,000 base pairs (bp), while one of its messengers RNA (mRNAs) measures only ...

Adding these methyl groups enhances RNA stability; however ... Since the degradation of most proteins is mediated by E3 ubiquitin ligases, the team further investigated and identified DTX2 ...

Because small RNA-producing loci are also small RNA targets in most of ... In this study, we show that Ema2, the conjugation-specific E3 ligase for a small ubiquitin-like modifier (SUMO), is required ...

Ubiquitin-mediated proteasomal degradation is a post-transcriptional protein modification that is comprised of various components including the 76-amino acid protein ubiquitin (Ub), Ub-activating ...

Tripartite motif-containing protein 25 (TRIM25), an E3 ubiquitin ligase, is pivotal for RIG-I ubiquitination ... The expression of viral RNA and proteins was significantly lower in cells over ...

RNA virus infections are detected by the RIG-I family of receptors ... TRAF6 and LUBAC relay the antiviral signal by binding to MAVS. These so-called ‘E3 ligases’ string ubiquitin together in chains ...