Frontiers18d
The role of miR-200 family in the regulation of hallmarks of cancer
MiRNAs are short non-coding RNAs that regulate gene expression post-transcriptionally contributing to the development of different diseases including cancer. The miR-200 family consists of five ...
The EMBO Journal18d
Kick-starting the zygotic genome: licensors, specifiers, and beyond
This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...
Medscape24d
Molecules (Basel, Switzerland)
Quantitative and Differential Analysis between Bupleurum chinense DC. and Bupleurum scorzonerifolium Willd. Using HPLC-MS and GC-MS Coupled with Multivariate Statistical Analysis. Comparative ...
eLife4y
MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may ...
Frontiers4y
DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner
The bromodomain-containing protein BRD4 has been thought to transmit epigenetic information across cell divisions by binding to both mitotic chromosomes and interphase chromatin. UV-released BRD4 ...
eLife8y
Real-time imaging of Huntingtin aggregates diverting target search and gene transcription
Two-color super resolution imaging reveals that mHtt aggregates exclude chromatin and selectively interact with a set of neurological disease-related factors (Foxp2, TBP, Sp1 and wild-type Huntingtin) ...