The series chronicles the early evolution of the Bene Gesserit order into a superpowered mystical sisterhood with great political power.

Prophecy centers entirely around the origins of the Bene Gesserit, known only as "the Sisterhood" in the show. However, there's a very simple reason for that. "The Sisterhood at its inception is not called the Bene Gesserit,

Giving space-witch vibes without space-witch powers… yet The premise of Dune: Prophecy, the latest sci-fi/fantasy lit juggernaut to hit the Max streaming service, is that it’s a show about the rise of the Bene Gesserit order.